Job Details

Mitochondria-Lysosome Crosstalk in Aging and Senescence - Zhou, Hansen, and Andersen Labs

POSITION SUMMARYThe Zhou, Hansen, and Andersen Labs at the Buck Institute for Research on Aging are jointly seeking a highly motivated Postdoctoral Researcher to explore the molecular mechanisms of mitochondrialysosome crosstalk in aging and cellular senescence. This collaborative project spans multiple model systems from cellular models to multicellular organisms such as C. elegans to address how organelle dysfunction contributes to aging and age-related diseases.Mitochondrial dysfunction and lysosomal impairment are conserved hallmarks of aging and central drivers in neurodegenerative diseases, such as Alzheimers. This position offers a unique opportunity to work at the interface of cell biology, aging research, and systems-level analysis, using a wide range of cutting-edge technologies:

• Genetic screening and molecular biology
• Super-resolution and cryo-electron microscopy
• High-throughput screening
• Quantitative image analysis and machine learning

The postdoctoral researcher will be co-mentored by three PIs, with Dr. Zhou serving as the primary mentor, and will actively collaborate across labs to conduct cross-species, cross-disciplinary aging research. We welcome candidates who are curious, ambitious, and eager to uncover fundamental biological principles with translational relevance to age-related diseases.

WE OFFER

• A highly collaborative, innovative environment for aging research in theSan Francisco Bay Area
• $71,845 - $80,000 postdoc salary range (commensurate with level & experience)
• Generous benefits package includes health insurance, paid parental leave, vacation/sick leave, and 401(k) with a 5% employer match and student loan repayment option

• Ph.D. in molecular biology, cell biology, biochemistry, genetics, neuroscience, or a related field
• Strong experimental background in cellular or organismal models
• Prior experience with microscopy, organelle biology, or aging/senescence studies is a plus
• Ability to work independently and collaboratively in a highly interdisciplinary environment

Please submit a current CV, 3 professional references, and a cover letter addressing your past research experience, plans, and expectations for working in the labs. For questions, contact Dr. Zhou via email (...@buckinstitute.org ).

Our success will ultimately change healthcare. At the Buck, we aim to end the threat of age-related diseases for this and future generations by bringing together the most capable and passionate scientists from a broad range of disciplines to identify and impede the ways in which we age. We are an independent, nonprofit institution located in Marin County, CA, with the goal of increasing human healthspan, or the healthy years of life. Globally recognized as the pioneer and leader in efforts to target agingthe number one risk factor for diseases including Alzheimers, Parkinsons, cancer, macular degeneration, heart disease, and diabetesthe Buck seeks to help people live better longer. Learn more at: